Technical insights: Why medshield oxygen absorber is essential to medicines

At the current hospital or clinic circumstances, infusion therapy, or should be noted as the standard procedure for inflammation, injection need, recovery, anti-neoplastic therapy, vitamin body strength, are really common and a direct and efficient method of drug administration. However, the safety and effectiveness has always been the concern for many doctors and patients. And today, our Oxygen Absorber is the cure to this conditions, these medicines includes not only amino acid, par-enteral nutrition, antibiotic products, anti-neoplastic products, vitamin medicines, three-chamber nutrient postoperative bag(Most critical), but also any medicine or pharmaceutical products that involve oil, proteins, vitamins, antibiotics and needed 100% no oxygen inside.

Technique facts:

1. （passes the 2020 edition of the Chinese Pharmacopoeia, specifically the general rules 0821 (first method of heavy metal detection), 1105 and 1106 (total aerobic bacteria performance standards).）

2. （Rapid oxygen uptake efficiency: in accordance with industry standard T/CNPPA 2004-2017）

3. （Breakthrough resistance to moisture and heat: verified by steam sterilisation at 121℃ for 15 - 30 minutes.）

4. HD Oxygen Absorber Unique mechanism that only Medshield has in the World（The humidity switching mechanism offers dual-mode free choice of humidity-controlled or hygroscopic type, allowing adjustment for extreme dry or hygroscopic drugs.）

IV bag, or noted as infusion bag, often contain different ingredients such as proteins, vitamins, and antibiotics, they are extremely sensitive to oxygen. Chemical reaction happens when the ingredients touches oxygen, and that normally happens at the production and sealing phase, sometimes happens when manufacturer uses not equitable outer packaging and causes oxygen permeating. All of these dangerous situation may trigger a series of very horrible chemical reactions which are the molecular structure of medicines’ proteins will be destroyed, leading to the loss of efficacy, and later on causes the total therapy to collapse. On the other hand, vitamins are oxidized and deteriorated which will become harmful substances, even harm patients life. Antibiotics are the most critical scenario, Oxygen will effect their efficacy due to oxidative decomposition, and even induce allergic reactions, and sometimes allergic reaction will cost life, it needed serious attention.

The fundamental ability of our oxygen absorber is to control the oxygen percentage within the package of IV bag to below 0.1%(Or any other number, all can be designed) through multiple chemical absorption, creating an almost/entirely oxygen-free storage circumstances for both liquid and solid medicines/pharmaceutical products.

Research data from a our R&D chemical reaction lab shows that under the same storage conditions, almost all the shelf life of infusion drugs or medicines using our oxygen absorbers will be extended by more than 58% of their time. And the chances of drugs/medicines’ oxidization will be reduced by more than 73%. Medshield’s technology is of great significance for drug preservation in remote areas and long-term preservation of emergency medical supplies.

l （Solid application Oxygen Absorption Balancing Humidity: Long term oxygen absorption process to control the RH balance at 40-50% in the package and continuous oxygen absorption as long as 7 days.）

We are research based, production next, 30years enterprises, invented the first ever China’s Oxygen Absorber back in 1980s, Nanjing Tianhua Packaging Technology Co., Ltd. officially launches its core product - Liquid/Solid-Application Oxygen Absorber, suited for many type of different nutrition IV bag, different acid IV bag, multiple solid-dose anti-neoplastic product and more. With our excellent oxygen absorption technology, very strict quality standards and compliance certification, our product has become the preferred solution for many domestic and foreign pharmaceutical enterprises to ensure the stability of liquid preparations, injecting strong impetus into the safety of the pharmaceutical supply chain.

l （One package for all applications: conventional oxygen absorber that can be used in a wide range of applications such as devices, medicines and content packaging.）

Technical insight: data upon reveal Oxygen Absorbers’ secret

Our Liquid-Application oxygen absorber for not only infusion bag such as different acid and nutrition three-chamber bag, but also anti-neoplastic product and vitamin and antibiotics products. Can be designed into different ingredients due to different needs. Normally uses iron powder as the core raw material, combined with auxiliary ingredients such as activated carbon and diatomite. Through spontaneous oxidation reaction, it can reduce the oxygen concentration in the inter-layer space between the inner and outer bags of the infusion bag to below 0.1% within 48 hours, and the total oxygen absorption capacity reaches 3 times the rated specification (under the condition of 25±2℃/40~60%RH). This feature is particularly critical for oxygen-sensitive drugs - by continuously isolating oxygen damage, it can significantly extend the shelf life of drugs and ensure the stability of their ingredients during production, circulation and storage.

For our customer to fully aware, our Liquid-Application oxygen absorber or solid-application oxygen absorber for not only infusion bag such as different acid and nutrition three-chamber bag, but also anti-neoplastic product and vitamin and antibiotics products. Can be designed to use high-density polyethylene non-woven fabric as the packaging material, or 100% fully sustainable packaging material(FDA approved) which not only has excellent physical and chemical properties (such as anti-particle pollution, waterproof and breathable, high tensile strength and puncture resistance), but also fully meets the relevant standards of FDA and the European Union, such as the sustainable requirements in the EU area. The non-toxic, tasteless and odorless characteristics fully meet the strict requirements of pharmaceutical packaging. In addition, the oxygen absorber can withstand high-temperature and high-pressure sterilization, adapting to the production process of various infusion bags, providing pharmaceutical enterprises with flexible and convenient application solutions.

Data reveal indicators’ secret

Oxygen indicator

Product Advantage

l （Breakthrough resistance to moisture and heat: verified by steam sterilisation at 121℃ for 15 - 30 minutes.）

l （The product is available with either unidirectional or bidirectional channels. Reversible colour change for oxygen in the package.）

Carbon dioxide indicator

Product Advantage

（extends beyond conventional market’s majority transitioning of purple to yellow, offering a more intuitive sense of blue to yellow contrast (hue ring 120 degrees or more). with customizable green-to-yellow transition packages available for specific monitoring protocols..）

（All models feature integrated reversible color-changing capability for continuous real-time monitoring of packaging integrity failures, enabling immediate visual detection of leaks, rework requirements, and seal compromise throughout the product lifecycle）

Canister Oxygen absorber

Product Advantage

l （This product has been verified as compatible with high-speed capping, with a minimum production rate of 200 bottles per minute.）

l Reduce labor cost

Compatible production line customization with our automated dispensers machine(custom options available upon request.)

l （The product incorporates an intelligent activation mechanism that is triggered automatically whenever the humidity reaches 40%RH.）

Stable performance across -20℃ to 40℃

30 Year customer services standard: Customized Solutions + Full-process Technical Support

In order to meet the needs of different limitation and restraint worldwide, Our Liquid-Application oxygen absorber and solid-application oxygen absorber for infusion bags and solid medicines provide a full range of specifications from 10ml to 1000ml, and 1g to 10g, also, special size can be customize-able upon request. Medshield professional technical team will provide its 100% customers support with full-process from product selection to actual installation testing, and it is recommended that customers verify the oxygen absorption effect and compatibility with infusion bags through actual installation testing in the form of actual commodities before actual use.

In terms of ease of use, the Liquid-Application oxygen absorber and solid-application oxygen absorber has two type of packaging, type A is high-barrier vacuum packaging, which can be operated within 1.5 hour after opening, and the remaining products can be stored continuously after being sealed. Type B is roll form, it can be equip with Medshield special designed machines to fit right into a production line, with no more labor costs, you pharmaceutical products will be 100% guarded by Medshield. All or our product needs to be stored in a dark and cool place, with a validity period of up to 2 years, effectively reducing the inventory management cost of pharmaceutical enterprises.